Nephrotic syndrome secondary to lithium therapy.

Overt nephrotic syndrome developed in a young housewife treated with lithium carbonate from manic-depressive psychosis. Complete spontaneous remission was observed 1 month after discontinuing the drug but the nephrotic state reappeared 8 years later when lithium therapy was re-instituted. The renal biopsy showed minimal glomerular lesions without interstitial disease.