一种新的甲硫氨酸脑啡肽类似物可抑制人体血浆中的血管加压素。

A new Met-enkephalin analogue suppresses plasma vasopressin in man.

作者信息

Zerbe R L, Henry D P, Robertson G L

出版信息

Peptides. 1982 Mar-Apr;3(2):199-201. doi: 10.1016/0196-9781(82)90051-1.

Abstract

Metkephamid acetate, a newly synthetized analogue of methionine enkephalin, suppressed plasma vasopressin levels from 2.4 pg/ml to 0.8 pg/ml after intramuscular administration to 4 normal human volunteers. This suppression occurred in the absence of significant changes in either plasma osmolality or blood pressure. Thus, metkephamid acetate, like many other opiates which bind to the mu subtype of opiate receptors, has a direct suppressive effect on plasma vasopressin levels.

摘要

醋酸美他啡肽，一种新合成的甲硫氨酸脑啡肽类似物，在对4名正常人类志愿者进行肌肉注射后，可将血浆血管加压素水平从2.4 pg/ml降至0.8 pg/ml。这种抑制作用发生时，血浆渗透压和血压均无显著变化。因此，醋酸美他啡肽与许多其他与阿片受体μ亚型结合的阿片类药物一样，对血浆血管加压素水平具有直接抑制作用。