Powell J R, Okada R, Conrad K A, Guentert T W, Riegelman S
Postgrad Med J. 1982 Feb;58(676):82-4. doi: 10.1136/pgmj.58.676.82.
A 49-year-old female with chronic active hepatitis and ventricular ectopic activity was given i.v. 600 mg quindine gluconate (4·4 mg/kg). Quinidine plasma concentrations were analysed by high pressure liquid chromatography and plasma protein binding by equilibrium dialysis. The pharmacokinetic values were total body clearance 0·11 l/kg/hr, elimination half-life 41·5 hr, volume of the central compartment 2·26 l/kg, volume of distribution from the area under the curve 6·5 l/kg, and 19% unbound in plasma. Based on the limited information available, quinidine dosing should be markedly decreased in patients with severe liver dysfunction.
一名患有慢性活动性肝炎且有室性异位活动的49岁女性静脉注射了600毫克葡萄糖酸奎尼丁（4.4毫克/千克）。通过高压液相色谱法分析奎尼丁血浆浓度，并通过平衡透析法分析血浆蛋白结合情况。药代动力学值为总体清除率0.11升/千克/小时，消除半衰期41.5小时，中央室容积2.26升/千克，曲线下面积分布容积6.5升/千克，血浆中19%未结合。基于现有有限信息，严重肝功能不全患者的奎尼丁给药剂量应显著降低。
