Mühlenbruch B, Strauss H, Glaubitz H
Pharmazie. 1982 Mar;37(3):200-3.
The dissolution rate constants of dihydrocodein in two retard drug dosage forms based on synthetic ion exchange resin were determined with four dissolution methods. The usage of the flow cell, rotationsdisk method and half-change method with a new dissolution model gave comparable results. Using the paddle apparatus the dissolution is very quick. There is only a small influence on the dissolution rate by the pH. A higher ionic strength of the dissolution medium increases the dissolution rate.
采用四种溶出方法测定了基于合成离子交换树脂的两种缓释药物剂型中双氢可待因的溶出速率常数。使用流通池、转碟法和采用新溶出模型的半变变法得到了可比的结果。使用桨板装置时溶出非常快。pH值对溶出速率的影响很小。溶出介质较高的离子强度会提高溶出速率。
