Nöschel H, Schröder S, Eichhorn K H, Peiker G
Pharmazie. 1982 Mar;37(3):204-5.
After oral administration of 300 mg of nitrofurantoin (Nifurantin) to various groups of pregnants, to women in labour and nonpregnant women the blood level and renal excretion of nitrofurantoin were investigated. We stated that gravidity, pyelonephritis and EPH-gestosis did not alter neither the renal excretion nor the blood level. In contrast to this during labour the renal elimination of nitrofurantoin was diminished and the blood concentration was enhanced. The biotransformation of nitrofurantoin seems not to be changed by pregnancy.
对不同组别的孕妇、临产妇女和非孕妇口服300毫克呋喃妥因（硝呋妥因）后，对呋喃妥因的血药浓度和肾排泄情况进行了研究。我们发现，妊娠、肾盂肾炎和妊娠高血压综合征既不改变肾排泄，也不改变血药浓度。与此相反，在分娩过程中，呋喃妥因的肾清除率降低，血药浓度升高。妊娠似乎不会改变呋喃妥因的生物转化。
