4-羟基-5-硝基-4,5-二氢胸腺嘧啶某些酯类对肿瘤细胞生长的抑制作用
Inhibitory effect of some esters of 4-hydroxy-5-nitro-4,5-dihydrothymine on the growth of tumor cells.
作者信息
Comes R, Postescu I D, Mustea I
出版信息
Pharmazie. 1982 Apr;37(4):283-5.
PMID:7100253
Abstract
New analogs of 4-hydroxy-5-nitro-4,5-dihydrothymine, namely 4-acyloxy-5-nitro-4,5-dihydrothymines (where: acyl = acetyl, benzoyl, mono- and dichloroacetyl) were synthesized and tested for their toxicologic and antitumor effects on Ehrlich ascites tumor cells and Ehrlich solid tumor. Best results were found for the mono- and dichloroacetyl derivatives.
摘要
合成了4-羟基-5-硝基-4,5-二氢胸腺嘧啶的新类似物，即4-酰氧基-5-硝基-4,5-二氢胸腺嘧啶（其中：酰基=乙酰基、苯甲酰基、一氯乙酰基和二氯乙酰基），并测试了它们对艾氏腹水瘤细胞和艾氏实体瘤的毒理学和抗肿瘤作用。一氯乙酰基和二氯乙酰基衍生物的效果最佳。
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