新型抗癌化合物酞氨芥的评估。II. 对小鼠艾氏腹水癌和肉瘤-180的肿瘤抑制作用
Evaluation of phthalmustine, a new anticancer compound. II. Tumor inhibitory effect in murine Ehrlich ascites carcinoma and sarcoma-180.
作者信息
Bhattacharya S, Ghosh M, Sadhu U, Dutta S, Sanyal U
机构信息
Department of Chemotherapy, Chittaranjan National Cancer Institute, Calcutta, India.
出版信息
Neoplasma. 1996;43(3):209-13.
The antitumor activity of phthalmustine (Neoplasma, 41, 1994, 35) has been evaluated in murine Ehrlich ascites carcinoma (EAC) and sarcoma-180 (S-180). The hematological changes associated with the application of phthalmustine were also evaluated in tumor bearing as well as in normal male Swiss mice. The results indicate that phthalmustine induces marked inhibition of tumor growth and substantially prolongs host survival having curative effect while it does not adversely affect hematopoiesis at the optimum dose tested. No toxic symptoms were noted with respect to external appearance, body weight changes and behavioral pattern.
已在小鼠艾氏腹水癌（EAC）和肉瘤-180（S-180）中评估了眼氨芥（《肿瘤》，41，1994，35）的抗肿瘤活性。还在荷瘤以及正常雄性瑞士小鼠中评估了与应用眼氨芥相关的血液学变化。结果表明，眼氨芥在测试的最佳剂量下可显著抑制肿瘤生长并大幅延长宿主存活期，具有治愈效果，同时对造血功能无不利影响。在外观、体重变化和行为模式方面未观察到毒性症状。
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