Schubert H, Fleischhacker W W, Demel I
Pharmacopsychiatria. 1982 May;15(3):103-6. doi: 10.1055/s-2007-1019518.
10 patients suffering from endogenomorphic depression on the basic of organic brain lesion were treated with 40 mg bromocriptin daily. Therapeutical efficacy was evaluated by various psychometric methods and by clinical impression. A negative correlation between performance and the depressive syndrome could be shown. Amelioration proved to be short lived, only 2 patients showed satisfactory response over a longer period of time. nausea and vomiting were the most common side effects, one patient showed a fully reversible manic syndrome. Reasons for the application of bromocriptin on the basis of a "dopamine-deficit hypothesis", and the results of the study are discussed.
对10例基于器质性脑病变患有内源性抑郁症的患者，每日给予40毫克溴隐亭进行治疗。通过各种心理测量方法和临床印象评估治疗效果。结果显示表现与抑郁综合征之间存在负相关。改善效果被证明是短暂的，只有2例患者在较长一段时间内表现出满意的反应。恶心和呕吐是最常见的副作用，1例患者出现了完全可逆的躁狂综合征。基于“多巴胺缺乏假说”讨论了应用溴隐亭的原因以及该研究的结果。
