Enhancing effect of saccharated ferric oxide on human lymphocyte transformation in serum-free medium.

The effect of saccharated ferric oxide on the response of human peripheral lymphocytes to stimulation by phytohemagglutinin in serum-free medium was studied by measuring the incorporation of [3H]thymidine into DNA. The addition of saccharated ferric oxide resulted in a significant increase in [3H]thymidine uptake not only with mitogen added, but also without mitogen, suggesting that this compound itself was mitogenic.