Zbinden G, Beilstein A K
Toxicol Lett. 1982 May;11(3-4):289-97. doi: 10.1016/0378-4274(82)90163-1.
Two new anthracenediones with antineoplastic activities resembling those of the anthracycline antibiotics were studied in a rat cardiotoxicity model system. NCS-196473 was approx. 10-fold less toxic than doxorubicin and caused only minor electrocardiogram (ECG) changes. Its dihydroxyanalog NSC-279836 was somewhat more toxic than doxorubicin, caused marked leukopenia and induced ECG changes and moderate elevation of serum GOT, LDH and creatine phosphokinase (CK). Both anthracenediones induced marked alterations of mitochondrial structure in the heart but no dilatation of the sarcoplasmic reticulum and distortion of the contractile elements. It is concluded that the cardiotoxic effects of the anthracenediones are of a less specific nature than those caused by doxorubicin.
在大鼠心脏毒性模型系统中研究了两种具有类似于蒽环类抗生素抗肿瘤活性的新型蒽二酮。NCS-196473的毒性约比阿霉素低10倍，仅引起轻微的心电图（ECG）变化。其二羟基类似物NSC-279836的毒性比阿霉素略高，导致明显的白细胞减少，并引起心电图变化以及血清谷草转氨酶（GOT）、乳酸脱氢酶（LDH）和肌酸磷酸激酶（CK）的中度升高。两种蒽二酮均引起心脏线粒体结构的明显改变，但未引起肌浆网扩张和收缩成分扭曲。结论是，蒽二酮的心脏毒性作用比阿霉素引起的心脏毒性作用特异性更低。
