De Ley G, Weyne J, Demeester G, Leusen I
Stroke. 1982 Jul-Aug;13(4):499-504. doi: 10.1161/01.str.13.4.499.
The effect of intraventricular histamine on blood flow in the caudate nucleus of the cat was studied by means of the hydrogen clearance technique. Bilateral ventriculo-cisternal perfusion was installed. After a control period during which both lateral ventricles were perfused with mock CSF with the same composition, the drug under study was added to one side (experimental side) while the other side was perfused further with the control mock SCF (control side). At each point in time, blood flow at the experimental side was compared to that at the control side. Histamine (10(-3) M) caused a severe vasodilatation and this effect was completely antagonised by the H2-receptor blocker cimetidine (10(-2) M). Cimetidine had no vasoactive effects of itself in the concentration used. The H2-receptor agonist Dimaprit (10(-3) M) had a vasodilator effect although less important than histamine. Indirect evidence was gained that H1-receptors are not active in the vascular bed under study.
采用氢清除技术研究了脑室内组胺对猫尾状核血流的影响。建立了双侧脑室-脑池灌注。在对照期内，双侧脑室均用成分相同的模拟脑脊液灌注，之后将受试药物添加到一侧（实验侧），而另一侧继续用对照模拟脑脊液灌注（对照侧）。在每个时间点，将实验侧的血流与对照侧的血流进行比较。组胺（10⁻³ M）引起严重的血管舒张，这种作用被H2受体阻滞剂西咪替丁（10⁻² M）完全拮抗。在所使用的浓度下，西咪替丁本身没有血管活性作用。H2受体激动剂二甲双胍（10⁻³ M）具有血管舒张作用，尽管不如组胺重要。获得了间接证据表明H1受体在所研究的血管床中不活跃。
