López-García J A, Ramis C, Nicolau M C, Alemany G, Planas B, Rial R
Department of Biology and H.S., University of the Balearic Islands, Palma de Mallorca, Spain.
Pharmacol Biochem Behav. 1993 Jun;45(2):275-82. doi: 10.1016/0091-3057(93)90239-p.
The effect of pharmacological manipulation of histaminergic receptors in the caudate nucleus (CN) has been examined in rats previously submitted to inescapable electric shock to produce learned helplessness (LH). Histamine H1 agonist 2-tiazolylethyl amine (TEA) microinjection produced protective effects, preventing the activity and cognitive loss typical in LH. Injection of the H1 antagonist astemizole (AZ) produced effects symmetrical to those produced by TEA, further reducing activity and impairing cognitive functions. The histamine H2 agonist 4-methyl-histamine (4MH) produced a shift on the side preference for rotation that interfered in the learning tests and obscured the effects of this drug on LH. Injection of the H2 antagonist cymetidine (CYM) caused LH-like effects in control animals. Thus, brain histamine seems to play a relevant role in the control of motor and cognitive functions of the CN.
在先前遭受不可逃避电击以产生习得性无助（LH）的大鼠中，研究了尾状核（CN）中组胺能受体的药理学操纵作用。组胺H1激动剂2-噻唑基乙胺（TEA）微量注射产生了保护作用，防止了LH中典型的活动和认知丧失。注射H1拮抗剂阿司咪唑（AZ）产生了与TEA产生的作用对称的效果，进一步降低了活动并损害了认知功能。组胺H2激动剂4-甲基组胺（4MH）在旋转的侧偏好上产生了变化，这在学习测试中产生了干扰，并掩盖了该药物对LH的影响。注射H2拮抗剂西咪替丁（CYM）在对照动物中引起了类似LH的效应。因此，脑组胺似乎在CN的运动和认知功能控制中发挥着相关作用。
