[Reaction between endogenous opiates and human peripheral blood lymphocytes].

The radioreceptor method and determination of the content of cAMP in lymphocytes were used to study the interplay of met-enkephalin with human peripheral blood lymphocytes. The characteristics of specific binding of endogenous opiate with the cells, as well s a decrease in the activity of lymphocyte adenylate cyclase observed under the effect of met-enkephalin proved the presence of a specific interplay between the physiological concentrations of the opiate with lymphocytes. It is suggested that it is determined by the existence of two parallel mechanisms: a process having some features in common with the receptor binding and limited transport of the opiate inside the cell.