Homologous controlled-viscosity fibrin for endovascular embolization. Part I. Experimental development of the medium.

The author used a two-component adhesive (homologous fibrinogen and thrombin) to develop a medium with controllable rate and extent of setting and coagulation. After mixing with the radiopaque substance metrizamide, the material meets the criteria postulated for an endoarterial embolization medium: variable and controllable viscosity, elasticity after setting, absence of toxicity, radio-opacity, and adequate sterilizability. After setting, the fibrin medium is a clear, solid, but soft elastic substance clearly visible on the X-ray film even in fine structures.