Maheshwari U R, Schneider V S, McDonald J T, Brunetti A J, Leybin L, Newbrun E, Hodge H
Am J Clin Nutr. 1982 Aug;36(2):211-8. doi: 10.1093/ajcn/36.2.211.
In a program of studies of disuse osteoporosis, fluoride balances were determined in healthy men during ambulation and then during bed rest for 6 to 17 wk. Control subjects ingested basal diets containing 0.4 mg fluoride per day, whereas experimental subjects received 10-mg fluoride supplements in divided doses with meals. Fluoride and calcium were measured in diets, urine, and feces. Serum analyses included calcium and ionic fluoride. Fluoride balances during both phases were uniformly negative in control subjects (mean -0.46 mg/day) but uniformly positive in supplement subjects (mean +2.58 mg/day). Calcium balances were markedly negative during bed rest in both groups. Serum fluoride concentrations increased proportionally to fluoride intake, averaging 0.016 ppm in the controls and 0.045 ppm in the supplement subjects. The supplement of 10 mg fluoride daily did not protect against bed rest-induced calcium loss, or cause any clinical or laboratory abnormality in any subject.
在一项废用性骨质疏松症的研究项目中，对健康男性在行走期间以及随后卧床休息6至17周期间的氟平衡进行了测定。对照组受试者摄入的基础饮食中每天含有0.4毫克氟，而实验组受试者则分剂量与餐同服10毫克氟补充剂。对饮食、尿液和粪便中的氟和钙进行了测量。血清分析包括钙和离子氟。在两个阶段，对照组受试者的氟平衡均呈一致的负值（平均-0.46毫克/天），但补充剂组受试者的氟平衡均呈一致的正值（平均+2.58毫克/天）。两组在卧床休息期间钙平衡均显著为负。血清氟浓度与氟摄入量成比例增加，对照组平均为0.016 ppm，补充剂组受试者平均为0.045 ppm。每天补充10毫克氟并不能预防卧床休息引起的钙流失，也未在任何受试者中引起任何临床或实验室异常。
