Danielides I, Van Devender G, Anch M
Am J Gastroenterol. 1982 Aug;77(8):535-8.
Diffuse esophageal spasm is a disease of unknown etiology in which neural or muscular control mechanisms malfunction, resulting in impaired and sometimes painful swallowing response, and inappropriate muscular contraction. An association between social stresses and disease activity suggesting elements of central control has been observed. In an effort to uncouple conscious central mechanisms from end organ response, we manometrically studied esophageal activity of four patients with symptomatic diffuse esophageal spasm while asleep (identified by electroencephalographic monitoring) as compared to wakeful states. We observed significant decreases from awake studies in number and duration of spontaneous contraction, during all sleep stages. We conclude that CNS mechanisms participate in the expression of the abnormal excitability of the esophagus in symptomatic diffuse esophageal spasm.
弥漫性食管痉挛是一种病因不明的疾病，其中神经或肌肉控制机制发生故障，导致吞咽反应受损，有时伴有疼痛，以及肌肉收缩异常。已观察到社会压力与疾病活动之间的关联，提示存在中枢控制因素。为了将有意识的中枢机制与终末器官反应分开，我们通过测压法研究了4例有症状的弥漫性食管痉挛患者在睡眠状态（通过脑电图监测确定）与清醒状态下的食管活动。我们观察到，在所有睡眠阶段，与清醒研究相比，自发收缩的数量和持续时间均显著减少。我们得出结论，中枢神经系统机制参与了有症状的弥漫性食管痉挛中食管异常兴奋性的表达。
