气管内注入纳洛酮治疗海洛因过量

Treatment of heroin overdose with endotracheal naloxone.

作者信息

Tandberg D, Abercrombie D

出版信息

Ann Emerg Med. 1982 Aug;11(8):443-5. doi: 10.1016/s0196-0644(82)80045-0.

Abstract

A 24-year-old man with respiratory failure, severe bradycardia, and coma following heroin overdose was successfully resuscitated using endotracheally administered naloxone hydrochloride (Narcan). Post-treatment naloxone assays demonstrated the presence of large amounts of naloxone in the patient's blood and urine. Serial serum naloxone levels over the ensuing three hours showed pharmacokinetics which appear similar to those previously reported for intravenous naloxone.

摘要

一名24岁男性在过量服用海洛因后出现呼吸衰竭、严重心动过缓和昏迷，经气管内给予盐酸纳洛酮（纳康）成功复苏。治疗后纳洛酮检测显示患者血液和尿液中存在大量纳洛酮。在随后三小时内连续检测的血清纳洛酮水平显示出的药代动力学与先前报道的静脉注射纳洛酮的药代动力学相似。