Schatz M, Wasserman S, Patterson R
Arch Intern Med. 1982 Aug;142(8):1515-9. doi: 10.1001/archinte.1982.00340210113021.
Current concepts regarding the morphology, constituents, distribution, and kinetics of the eosinophil allow an expanded understanding of the eosinophil's function in health and disease. In particular, certain eosinophil constituents may have beneficial effects (modulation of mast cell-dependent reactions and helminthotoxic properties), while others may produce detrimental effects (tissue destruction). Eosinophils may be clinically important in obstructive and infiltrative pulmonary diseases. In obstructive disease, a peripheral eosinophilia indicates reversibility, and the magnitude of the peripheral eosinophil count correlates with the severity of the reversible obstruction. Concerning infiltrative pulmonary disease, an updated classification of pulmonary infiltrates with eosinophilia, which is based on recognizable causes and syndromes, is presented, and allergic bronchopulmonary aspergillosis, chronic eosinophilic pneumonia, drug reactions, the hypereosinophilic syndrome, parasitic infestations, and the Churg-Strauss syndrome are specifically considered.
目前关于嗜酸性粒细胞的形态、成分、分布和动力学的概念，使人们对嗜酸性粒细胞在健康和疾病中的功能有了更广泛的认识。特别是，某些嗜酸性粒细胞成分可能具有有益作用（调节肥大细胞依赖性反应和抗蠕虫毒性），而其他成分可能产生有害作用（组织破坏）。嗜酸性粒细胞在阻塞性和浸润性肺部疾病中可能具有临床重要性。在阻塞性疾病中，外周血嗜酸性粒细胞增多表明病变具有可逆性，外周血嗜酸性粒细胞计数的高低与可逆性阻塞的严重程度相关。关于浸润性肺部疾病，本文提出了一种基于可识别病因和综合征的嗜酸性粒细胞增多性肺部浸润的最新分类方法，并特别考虑了变应性支气管肺曲霉病、慢性嗜酸性粒细胞性肺炎、药物反应、高嗜酸性粒细胞综合征、寄生虫感染和变应性肉芽肿性血管炎。
