• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

盐敏感和盐抵抗大鼠的血浆盐皮质激素、血浆肾素和尿激肽释放酶

Plasma mineralocorticoids, plasma renin, and urinary kallikrein in salt-sensitive and salt-resistant rats.

作者信息

Rapp J P, Tan S Y, Margolius H S

出版信息

Endocr Res Commun. 1978;5(1):35-41. doi: 10.3109/07435807809073634.

DOI:10.3109/07435807809073634
PMID:710365
Abstract

Plasma aldosterone, deoxycorticosterone (DOC), 18-hydroxy-deoxycorticosterone (18OH-DOC), and corticosterone were measured in Dahl salt-sensitive (S) and salt-resistant (R) rats. Plasma corticosterone and DOC were not different between strains but plasma aldosterone was decreased and plasma 18OH-DOC increased in S compared to R. Plasma renin activity and urinary kallikrein excretion were both lower in S than R. Urinary kallikrein is known to vary directly with mineralocorticoid activity and 18OH-DOC is a weak mineralocorticoid. The lower urinary kallikrein in the presence of elevated 18OH-DOC could mean that urinary kallikrein differences between S and R are under independent genetic control from 18OH-DOC.

摘要

在 Dahl 盐敏感（S）大鼠和盐抵抗（R）大鼠中测量了血浆醛固酮、脱氧皮质酮（DOC）、18-羟基脱氧皮质酮（18OH-DOC）和皮质酮。两品系大鼠的血浆皮质酮和 DOC 没有差异，但与 R 大鼠相比，S 大鼠的血浆醛固酮降低，血浆 18OH-DOC 升高。S 大鼠的血浆肾素活性和尿激肽释放酶排泄均低于 R 大鼠。已知尿激肽释放酶与盐皮质激素活性直接相关，且 18OH-DOC 是一种弱盐皮质激素。在 18OH-DOC 升高的情况下尿激肽释放酶较低，这可能意味着 S 大鼠和 R 大鼠之间尿激肽释放酶的差异受 18OH-DOC 独立的基因控制。

相似文献

1
Plasma mineralocorticoids, plasma renin, and urinary kallikrein in salt-sensitive and salt-resistant rats.盐敏感和盐抵抗大鼠的血浆盐皮质激素、血浆肾素和尿激肽释放酶
Endocr Res Commun. 1978;5(1):35-41. doi: 10.3109/07435807809073634.
2
Anomalous response of urinary kallikrein to deoxycorticosterone in Dahl salt-sensitive rats.在 Dahl 盐敏感大鼠中尿激肽释放酶对脱氧皮质酮的异常反应。
Hypertension. 1982 Jan-Feb;4(1):20-6. doi: 10.1161/01.hyp.4.1.20.
3
Relationship of 19-nor-deoxycorticosterone to other mineralocorticoids in low-renin hypertension.
Hypertension. 1983 May-Jun;5(3):385-9. doi: 10.1161/01.hyp.5.3.385.
4
Paper chromatographic systems for the separation of aldosterone, 18-hydroxycorticosterone, 18-hydroxydeoxycorticosterone, corticosterone and deoxycorticosterone.
J Chromatogr. 1980 Sep 26;198(1):70-5. doi: 10.1016/s0021-9673(00)81198-x.
5
The mineralocorticoid hormone pathways in hypertension with hyperaldosteronism.伴有醛固酮增多症的高血压中的盐皮质激素激素途径。
Clin Exp Hypertens A. 1982;4(9-10):1677-83. doi: 10.3109/10641968209061633.
6
Inappropriate elevation of the aldosterone/plasma renin activity ratio in hypertensive patients with increases of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone: a subtype of essential hypertension?醛固酮/血浆肾素活性比值在高血压患者中不适当升高，同时伴有11-脱氧皮质酮和18-羟基-11-脱氧皮质酮升高：原发性高血压的一种亚型？
Cardiology. 1991;78(2):99-110. doi: 10.1159/000174773.
7
Rapid increase of mineralocorticoids after furosemide in low-renin essential hypertension: evidence for 18-hydroxycorticosterone to be a better marker than aldosterone.速尿后低肾素性原发性高血压患者盐皮质激素迅速增加：18-羟皮质酮作为比醛固酮更好标志物的证据
Klin Wochenschr. 1982 Aug 16;60(16):847-52. doi: 10.1007/BF01728351.
8
Steroid induced changes of the renal kallikrein-kinin system in rats.类固醇诱导大鼠肾激肽释放酶-激肽系统的变化。
Acta Endocrinol (Copenh). 1984 Sep;107(1):131-40. doi: 10.1530/acta.0.1070131.
9
Effect of ACTH administration on urinary kallikrein excretion in man.促肾上腺皮质激素给药对人体尿激肽释放酶排泄的影响。
Clin Exp Pharmacol Physiol. 1984 Jan-Feb;11(1):87-90. doi: 10.1111/j.1440-1681.1984.tb00243.x.
10
Effect of metoprolol on 24-hour urinary excretion of adrenal steroids and kallikrein in patients with essential hypertension.美托洛尔对原发性高血压患者肾上腺类固醇及激肽释放酶24小时尿排泄量的影响。
Br J Pharmacol. 1984 Feb;81(2):245-53. doi: 10.1111/j.1476-5381.1984.tb10071.x.

引用本文的文献

1
Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.迈向高血压的精准医学：实验大鼠模型和人类中基因组、表观基因组及微生物组对血压影响的综述
Physiol Rev. 2017 Oct 1;97(4):1469-1528. doi: 10.1152/physrev.00035.2016.
2
A Novel Category of Anti-Hypertensive Drugs for Treating Salt-Sensitive Hypertension on the Basis of a New Development Concept.基于新发展理念的治疗盐敏感性高血压的新型抗高血压药物类别
Pharmaceuticals (Basel). 2010 Jan 7;3(1):59-109. doi: 10.3390/ph3010059.
3
Proton channels and renal hypertensive injury: a key piece of the Dahl salt-sensitive rat puzzle?
质子通道与肾性高血压损伤：解开 Dahl 盐敏感大鼠之谜的关键一环？
Am J Physiol Regul Integr Comp Physiol. 2016 Apr 15;310(8):R679-90. doi: 10.1152/ajpregu.00115.2015. Epub 2016 Feb 3.
4
The role of transforming growth factor β1 in the regulation of blood pressure.转化生长因子β1在血压调节中的作用。
Curr Hypertens Rev. 2014;10(4):223-38. doi: 10.2174/157340211004150319123313.
5
Congenic mapping and sequence analysis of the Renin locus.同源基因映射与肾素基因座的序列分析。
Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4.
6
Molecular mechanisms of experimental salt-sensitive hypertension.实验性盐敏感性高血压的分子机制
J Am Heart Assoc. 2012 Jun;1(3):e002121. doi: 10.1161/JAHA.112.002121. Epub 2012 Jun 22.
7
Role of the epithelial sodium channel in salt-sensitive hypertension.上皮钠通道在盐敏感性高血压中的作用。
Acta Pharmacol Sin. 2011 Jun;32(6):789-97. doi: 10.1038/aps.2011.72. Epub 2011 May 30.
8
Role of mineralocorticoid action in the brain in salt-sensitive hypertension.脑内盐敏感性高血压的盐皮质激素作用。
Clin Exp Pharmacol Physiol. 2012 Jan;39(1):90-5. doi: 10.1111/j.1440-1681.2011.05538.x.
9
Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension.脑内醛固酮合成导致达尔大鼠盐敏感性高血压。
Exp Physiol. 2010 Jan;95(1):120-30. doi: 10.1113/expphysiol.2009.048900. Epub 2009 Oct 16.
10
Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats.睾酮依赖性高血压与 Dahl 盐敏感大鼠肾内血管紧张素原上调
Am J Physiol Renal Physiol. 2009 Apr;296(4):F771-9. doi: 10.1152/ajprenal.90389.2008. Epub 2009 Feb 11.