Tanaka K, Hirst A E, Smith L L
Arch Surg. 1982 Aug;117(8):1045-8. doi: 10.1001/archsurg.1982.01380320033009.
Little is known about the rate of endothelialization of venous thrombi. This study was performed to determine the time required for complete endothelialization of the head of standardized thrombi in medium-sized veins (4 to 5 mm) in dogs. This information was sought to help determine the optimal duration of anticoagulation therapy in patients with acute venous thrombi. While endothelial growth was observed as early as three days, endothelialization of the head of the thrombus was not complete until 14 days in seven of eight venous thrombi. These experimental findings suggest that therapeutic anticoagulation should be continued for at least ten to 14 days if maximum benefit is to be achieved.
关于静脉血栓的内皮化速率，人们了解甚少。本研究旨在确定犬中型静脉（4至5毫米）中标准化血栓头部完全内皮化所需的时间。获取该信息是为了帮助确定急性静脉血栓患者抗凝治疗的最佳持续时间。虽然早在三天就观察到内皮生长，但八个静脉血栓中有七个血栓头部的内皮化直到14天才完成。这些实验结果表明，如果要实现最大益处，治疗性抗凝应持续至少10至14天。
