苯妥英钠给药后美西律代谢增强。
Enhanced metabolism of mexiletine after phenytoin administration.
作者信息
Begg E J, Chinwah P M, Webb C, Day R O, Wade D N
出版信息
Br J Clin Pharmacol. 1982 Aug;14(2):219-23. doi: 10.1111/j.1365-2125.1982.tb01965.x.
Abstract
1 Unexpectedly low plasma concentrations of mexiletine were observed in three patients treated with mexiletine and concurrently taking phenytoin. 2 Six healthy volunteers were given a single oral dose of mexiletine (400 mg), before and after 1 week of phenytoin administration (300 mg/day). 3 The mean +/- s.d. area under the plasma mexiletine concentration-time curve decreased from 17.67 +/- 6.21 to 8.01 +/- 3.64 micrograms ml-1 h (P less than 0.003). 4 The mean +/- s.d. half-life of elimination of mexiletine decreased from 17.2 +/- 5.26 to 8.4 +/- 4.17 h (P less than 0.02) 5 The suggested mechanism of the interaction is hepatic mixed-function oxidase enzyme induction by phenytoin. 6 The interaction is likely to be clinically significant.
摘要
- 在三名接受美西律治疗且同时服用苯妥英钠的患者中，观察到美西律的血浆浓度意外降低。2. 六名健康志愿者在服用苯妥英钠（300毫克/天）1周前后，分别单次口服美西律（400毫克）。3. 血浆中美西律浓度-时间曲线下的平均±标准差面积从17.67±6.21降至8.01±3.64微克·毫升-1·小时（P<0.003）。4. 美西律消除的平均±标准差半衰期从17.2±5.26小时降至8.4±4.17小时（P<0.02）。5. 所提示的相互作用机制是苯妥英钠诱导肝混合功能氧化酶。6. 这种相互作用可能具有临床意义。
相似文献
1
Enhanced metabolism of mexiletine after phenytoin administration.苯妥英钠给药后美西律代谢增强。
Br J Clin Pharmacol. 1982 Aug;14(2):219-23. doi: 10.1111/j.1365-2125.1982.tb01965.x.
2
Stereoselective disposition of mexiletine in man.美西律在人体中的立体选择性分布。
Br J Clin Pharmacol. 1986 May;21(5):481-7. doi: 10.1111/j.1365-2125.1986.tb02829.x.
3
Mexiletine kinetics in healthy subjects taking cimetidine.服用西咪替丁的健康受试者的美西律动力学
Clin Pharmacol Ther. 1985 Jun;37(6):669-73. doi: 10.1038/clpt.1985.109.
4
The interaction of mexiletine with other cardiovascular drugs.美西律与其他心血管药物的相互作用。
Am Heart J. 1984 May;107(5 Pt 2):1079-85. doi: 10.1016/0002-8703(84)90178-9.
5
The effect of metoclopramide and atropine on the absorption of orally administered mexiletine.甲氧氯普胺和阿托品对口服美西律吸收的影响。
Br J Clin Pharmacol. 1980 May;9(5):505-9.
6
Pharmacokinetics of oral mexiletine in patients with acute myocardial infarction.急性心肌梗死患者口服美西律的药代动力学
Eur J Clin Pharmacol. 1983;25(6):773-7. doi: 10.1007/BF00542518.
7
Effect of rifampicin treatment on the kinetics of mexiletine.利福平治疗对美西律动力学的影响。
Eur J Clin Pharmacol. 1982;23(3):261-6. doi: 10.1007/BF00547565.
8
Kinetics and bioavailability of mexiletine in healthy subjects.美西律在健康受试者中的动力学和生物利用度。
Clin Pharmacol Ther. 1981 Jun;29(6):729-36. doi: 10.1038/clpt.1981.103.
9
Effect of cigarette smoking on mexiletine kinetics.吸烟对美西律药代动力学的影响。
Clin Pharmacol Ther. 1985 Jun;37(6):638-43. doi: 10.1038/clpt.1985.103.
10
Pharmacokinetics of mexiletine in renal insufficiency.
Acta Cardiol Suppl. 1980(25):55-65.
引用本文的文献
1
Sodium channel slow inactivation as a therapeutic target for myotonia congenita.钠通道缓慢失活作为先天性肌强直的治疗靶点。
Ann Neurol. 2015 Feb;77(2):320-32. doi: 10.1002/ana.24331. Epub 2015 Jan 9.
2
Antiarrhythmic agents: drug interactions of clinical significance.抗心律失常药物：具有临床意义的药物相互作用
Drug Saf. 2000 Dec;23(6):509-32. doi: 10.2165/00002018-200023060-00003.
3
Clinical pharmacokinetics of mexiletine.美西律的临床药代动力学。
Clin Pharmacokinet. 1999 Nov;37(5):361-84. doi: 10.2165/00003088-199937050-00002.
4
Mexiletine. A review of its therapeutic use in painful diabetic neuropathy.美西律。其在疼痛性糖尿病神经病变中治疗应用的综述。
Drugs. 1998 Oct;56(4):691-707. doi: 10.2165/00003495-199856040-00016.
5
Clinical pharmacokinetics of the newer antiarrhythmic agents.新型抗心律失常药物的临床药代动力学
Clin Pharmacokinet. 1984 Sep-Oct;9(5):375-403. doi: 10.2165/00003088-198409050-00001.
6
Cirrhosis of the liver markedly impairs the elimination of mexiletine.肝硬化会显著损害美西律的消除。
Eur J Clin Pharmacol. 1986;30(1):83-8. doi: 10.1007/BF00614201.
7
Pharmacokinetic drug interactions with phenytoin (Part II).苯妥英的药代动力学药物相互作用（第二部分）。
Clin Pharmacokinet. 1990 Feb;18(2):131-50. doi: 10.2165/00003088-199018020-00004.
本文引用的文献
1
Lignocaine disposition in blood in epilepsy.癫痫患者血液中利多卡因的处置情况
Br J Clin Pharmacol. 1981 Nov;12(5):663-6. doi: 10.1111/j.1365-2125.1981.tb01286.x.
2
The effect of enzyme induction on the metabolism of disopyramide in man.酶诱导对人丙吡胺代谢的影响。
Br J Clin Pharmacol. 1981 Mar;11(3):279-85. doi: 10.1111/j.1365-2125.1981.tb00535.x.
3
The effect of metoclopramide and atropine on the absorption of orally administered mexiletine.甲氧氯普胺和阿托品对口服美西律吸收的影响。
Br J Clin Pharmacol. 1980 May;9(5):505-9.
4
Mexiletine (Kö 1173) in the management of ventricular dysrhythmias.美西律（Kö 1173）用于室性心律失常的治疗。
Lancet. 1973 Aug 25;2(7826):404-7. doi: 10.1016/s0140-6736(73)92271-x.
5
Treatment of ventricular arrhythmias with mexiletine (Kö 1173).美西律（Kö 1173）治疗室性心律失常
Lancet. 1973 Aug 25;2(7826):399-404. doi: 10.1016/s0140-6736(73)92270-8.
6
Interaction of quinidine with anticonvulsant drugs.
N Engl J Med. 1976 Mar 25;294(13):699-702. doi: 10.1056/NEJM197603252941305.
7
Commentary: a physiological approach to hepatic drug clearance.述评：肝脏药物清除的生理学方法
Clin Pharmacol Ther. 1975 Oct;18(4):377-90. doi: 10.1002/cpt1975184377.
8
Malabsorption of frusemide caused by phenytoin.苯妥英钠导致速尿吸收不良。
Br Med J. 1977 Oct 22;2(6094):1061-2. doi: 10.1136/bmj.2.6094.1061.
9
Absorption, distribution and elimination of mexiletine.
Postgrad Med J. 1977;53 Suppl 1:50-5.
10
Measurement of plasma mexiletine concentrations.
Postgrad Med J. 1977;53 Suppl 1:48-9.
Zotero 插件