抗高血压药物拉贝洛尔对子宫胎盘血流的急性影响。

Acute effect of an antihypertensive drug, labetalol, on uteroplacental blood flow.

作者信息

Lunell N O, Nylund L, Lewander R, Sarby B

出版信息

Br J Obstet Gynaecol. 1982 Aug;89(8):640-4. doi: 10.1111/j.1471-0528.1982.tb04719.x.

DOI:10.1111/j.1471-0528.1982.tb04719.x

Abstract

The effect of a new antihypertensive drug, labetalol, on uteroplacental blood flow was determined in eight pre-eclamptic women. After injection of 0.5 mCi of 113mIn the radioactivity in the placenta was recorded by a gamma camera linked to a computer and the placental blood-flow index was calculated from the ratio between the maximum radioactivity of the isotope-accumulation curve and the rise time of the curve. Labetalol, a combined alpha- and beta-adrenoceptor antagonist was given intravenously and after 30 min a second uteroplacental blood-flow index was calculated. There was a significant mean decrease of blood pressure from 147/98 to 128/83 mmHg, but no change in uteroplacental blood-flow index, so that uteroplacental vascular resistance tended to decrease.

摘要

在8名先兆子痫女性中测定了一种新型抗高血压药物拉贝洛尔对子宫胎盘血流的影响。注射0.5毫居里的113mIn后，通过与计算机相连的γ相机记录胎盘的放射性，并根据同位素积累曲线的最大放射性与曲线上升时间的比值计算胎盘血流指数。拉贝洛尔是一种α和β肾上腺素能受体联合拮抗剂，通过静脉注射给药，30分钟后计算第二个子宫胎盘血流指数。血压显著平均从147/98 mmHg降至128/83 mmHg，但子宫胎盘血流指数没有变化，因此子宫胎盘血管阻力有下降趋势。