Horpacsy G, Zinsmeyer J, Mebel M
Eur Urol. 1978;4(5):334-7. doi: 10.1159/000473988.
We investigated changes in urinary enzyme activity and sodium concentration of kidney transplant patients. We found that the increase of the activity of brush border enzymes is one of the earliest signs of tubular damage following rejection. The decrease in the urinary sodium concentration points also to rejection episodes. Despite the unspecificity of both variables, their continuous determination and combined analysis of the results could improve the differential diagnosis of rejection after transplantation and might give important information about the pathogenesis of the graft damage.
我们研究了肾移植患者尿酶活性和钠浓度的变化。我们发现，刷状缘酶活性增加是排斥反应后肾小管损伤的最早迹象之一。尿钠浓度降低也提示排斥反应发作。尽管这两个变量缺乏特异性，但对它们进行连续测定并综合分析结果，可能会改善移植后排斥反应的鉴别诊断，并可能提供有关移植物损伤发病机制的重要信息。
