Horpacsy G, May G, Zinsmeyer J, Mebel M
Urol Int. 1978;33(4):234-4. doi: 10.1159/000280204.
In 54 patients with graft failure the changes of urine sodium concentration and of urinary enzyme activities (alanine aminopeptidase, AAP) were investigated. It was found that: (1) the kidneys with irreversible acute tubular necrosis are characterised by high urine sodium level, and low AAP activities. These changes correspond to the end stage of renal insufficiency. (2) Low concentration of sodium and extremely high AAP excretion are characteristic in grafts with severe rejection episodes. (3) If kidneys lost their function due to irreversible rejection, the biochemical variables showed the same changes as in the first group. We concluded that by continuous determination of sodium levels and enzyme activities in urine and by their correlation it is possible to detect the non-functioning grafts in the early posttransplantation period.
对54例移植失败患者的尿钠浓度和尿酶活性（丙氨酸氨基肽酶，AAP）变化进行了研究。结果发现：（1）不可逆性急性肾小管坏死的肾脏，其特点是尿钠水平高，AAP活性低。这些变化与肾功能不全的终末期相符。（2）严重排斥反应的移植物，其特点是钠浓度低，AAP排泄极高。（3）如果肾脏因不可逆性排斥反应而丧失功能，生化指标变化与第一组相同。我们得出结论，通过持续测定尿钠水平和酶活性并进行相关性分析，有可能在移植后早期检测出无功能的移植物。
