Sinclair J G, Lo G F, Harris D P
Can J Physiol Pharmacol. 1982 May;60(5):610-4. doi: 10.1139/y82-082.
Ethanol (1.5 g/kg i.v.) was found to decrease spontaneous complex spike (CS) activity in cerebellar Purkinje cells in urethane anaesthetized rats while not changing the threshold required to evoke a CS by juxtafastigial stimulation. Thus ethanol does not decrease CS activity by an action at the climbing fibre-Purkinje cell synapse. Tremor induced by harmaline (5 mg/kg i.v.) in unanaesthetized animals was markedly antagonized by ethanol (0.5-2.0 g/kg i.v.) in all animals tested. However, in nine urethane-anaesthetized animals, ethanol markedly reversed the effects of harmaline on Purkinje cells in only two cases and partially reversed the effects in another four cells. Thus, the depressant effects of ethanol on the inferior olive is not total responsible for the blockade of the harmaline tremor bur would account for the decrease in spontaneous CS activity.
在氨基甲酸乙酯麻醉的大鼠中发现，静脉注射乙醇（1.5克/千克）可降低小脑浦肯野细胞的自发放电复合峰（CS）活动，而不改变旁顶核刺激诱发CS所需的阈值。因此，乙醇并非通过作用于攀缘纤维 - 浦肯野细胞突触来降低CS活动。在所有受试动物中，未麻醉动物中由哈马灵（静脉注射5毫克/千克）诱发的震颤被乙醇（静脉注射0.5 - 2.0克/千克）显著拮抗。然而，在9只氨基甲酸乙酯麻醉的动物中，乙醇仅在2例中显著逆转了哈马灵对浦肯野细胞的影响，在另外4个细胞中部分逆转了其影响。因此，乙醇对下橄榄核的抑制作用并非完全是阻断哈马灵震颤的原因，但可解释自发放电CS活动的降低。
