Vos O
Exp Hematol. 1978 Sep;6(8):688-93.
Multiple injections of S. typhosa LPS increased the number of CFU-S in the spleen 20-50 fold and decreased the number in the femur to one half or less. LPS injections did not affect the growth rates of CFU-S in the spleen or femur of lethally irradiated mice. The plateau levels which were attained in these mice after proliferation, corresponded with the levels in LPS-treated non-irradiated mice. Local irradiation of the spleen with 3000 rad hardly affected the capacity of the spleen to accommodate the increased CFU-S numbers after LPS injection. These results suggest that irradiation resistant microenvironmental factors in the spleen determine the CFU-S accumulation in this organ after injection of Salmonella typhosa LPS. The increased number of CFU-S in the blood after LPS injection was maintained in splenectomized mice as well as in mice which received a local splenic x-irradiation with 3000 rad, indicating that this rise of blood CFU-S numbers is independent of the spleen.
多次注射伤寒沙门氏菌脂多糖（S. typhosa LPS）可使脾脏中脾集落形成单位（CFU-S）的数量增加20至50倍，并使股骨中的数量减少至一半或更少。脂多糖注射并不影响致死性照射小鼠脾脏或股骨中CFU-S的生长速率。这些小鼠增殖后达到的平台水平与脂多糖处理的未照射小鼠中的水平相当。用3000拉德对脾脏进行局部照射几乎不影响脾脏在注射脂多糖后容纳增加的CFU-S数量的能力。这些结果表明，脾脏中抗辐射的微环境因素决定了注射伤寒沙门氏菌脂多糖后该器官中CFU-S的积累。脂多糖注射后血液中CFU-S数量的增加在脾切除小鼠以及接受3000拉德脾脏局部X射线照射的小鼠中均得以维持，这表明血液中CFU-S数量的这种增加与脾脏无关。
