Volans G N, Jeffereys D, Latham A N, Frost T
Curr Med Res Opin. 1982;8(1):51-3. doi: 10.1185/03007998209109757.
A randomized crossover study was carried out in 7 healthy subjects to investigate the pharmacokinetics of indoramin from two oral formulations (film-coated and uncoated 50 mg tablets) and to determine the effect of a standard mean on the plasma concentration time curve of the film-coated form. The results indicated that peak plasma concentrations occurred in 1 to 4 hours after treatment with a single dose of 2 tablets, with an overall elimination half-life of 5 hours. No significant differences could be shown between treatments in any of the pharmacokinetic variables determined. However, administration of film-coated indoramin after a standard meal narrowed the range of peak concentrations but the time at which peak concentrations of the drug occurred did not appear to be related to whether or not indoramin was given after the meal.
对7名健康受试者进行了一项随机交叉研究，以调查两种口服制剂（薄膜包衣和未包衣的50毫克片剂）中吲哚拉明的药代动力学，并确定标准餐对薄膜包衣剂型血浆浓度-时间曲线的影响。结果表明，单次服用2片后，血浆峰值浓度在治疗后1至4小时出现，总体消除半衰期为5小时。在所测定的任何药代动力学变量中，各治疗组之间均未显示出显著差异。然而，标准餐后服用薄膜包衣吲哚拉明使峰值浓度范围变窄，但药物达到峰值浓度的时间似乎与餐后是否服用吲哚拉明无关。
