Jaffe G, Grimshaw J J, Gay J, Hossain M
Curr Med Res Opin. 1982;8(2):75-81. doi: 10.1185/03007998209109761.
An open parallel study was carried out in general practice on 70 patients with uncomplicated mild to moderate hypertension to compare the hypotensive efficacy of hydrochlorothiazide/amiloride with that of cyclopenthiazide/potassium. After a 2-week baseline period on placebo, patients were allocated at random to receive treatment with one or other of the diuretics starting with 1 tablet per day and increasing up to a maximum of 4 tablets per day or until their supine diastolic blood pressure was 90 mmHg or less. They were then continued at their optimum dose for a further 4 weeks. Analysis of the results from 62 patients showed that the hydrochlorothiazide/amiloride preparation produced both a greater decrease and better control of blood pressure in a greater percentage of patients that did the comparison diuretic. In addition, the beneficial effects were attained with fewer tablets, of importance for patient compliance.
在普通医疗实践中对70例无并发症的轻至中度高血压患者进行了一项开放性平行研究，以比较氢氯噻嗪/阿米洛利与环戊噻嗪/钾的降压效果。在服用安慰剂的2周基线期后，患者被随机分配接受其中一种利尿剂治疗，开始时每天1片，最多增加至每天4片，或直至其仰卧位舒张压降至90mmHg或更低。然后以最佳剂量继续治疗4周。对62例患者的结果分析表明，与对照利尿剂相比，氢氯噻嗪/阿米洛利制剂在更大比例的患者中使血压下降幅度更大且控制效果更好。此外，达到有益效果所需的药片数量更少，这对患者的依从性很重要。
