Mummery R V
Curr Med Res Opin. 1982;8(2):97-103. doi: 10.1185/03007998209109764.
Twenty patients with a variety of serious or difficult infections and 5 additional orthopaedic patients with clinical evidence of post-operative wound infection were treated with netilmicin. The results indicate that twice daily dosage with 150 mg intramuscularly, either alone or in combination with other antibiotic therapy, was highly effective. Overall, 25 (96%) infections responded clinically and 19 (73%) were improved bacteriologically. There was no evidence of ototoxicity: a number of patients had impaired renal function which developed during therapy, but all returned to normal or pre-treatment levels by the time that treatment was completed, despite the fact that 15 patients were receiving diuretics. It is suggested in view of its effectiveness, more predictable serum levels after standard dosage and apparent lack of toxicity, that netilmicin should be considered as the first choice aminoglycoside antibiotic instead of gentamicin.
20名患有各种严重或难治性感染的患者以及另外5名有术后伤口感染临床证据的骨科患者接受了奈替米星治疗。结果表明，每日两次150mg肌肉注射的剂量，无论是单独使用还是与其他抗生素联合使用，都非常有效。总体而言，25例（96%）感染在临床上有反应，19例（73%）在细菌学上有所改善。没有耳毒性的证据：一些患者在治疗期间出现肾功能损害，但尽管有15名患者正在接受利尿剂治疗，所有患者在治疗结束时肾功能都恢复到正常或治疗前水平。鉴于其有效性、标准剂量后更可预测的血清水平以及明显缺乏毒性，建议将奈替米星视为首选的氨基糖苷类抗生素，而非庆大霉素。
