胰岛素通过降低线粒体乙酰辅酶A/辅酶A的比例来激活丙酮酸脱氢酶，这一点在分离的脂肪细胞经洋地黄皂苷分级分离后得到了证实。 - Suppr | 超能文献

Insulin activates pyruvate dehydrogenase by lowering the mitochondrial acetyl-CoA/CoA ratio as evidenced by digitonin fractionation of isolated fat cells.

作者信息

Paetzke-Brunner I, Schön H, Wieland O H

出版信息

FEBS Lett. 1978 Sep 15;93(2):307-11. doi: 10.1016/0014-5793(78)81127-2.

DOI:10.1016/0014-5793(78)81127-2

Abstract

摘要

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Insulin activates pyruvate dehydrogenase by lowering the mitochondrial acetyl-CoA/CoA ratio as evidenced by digitonin fractionation of isolated fat cells.胰岛素通过降低线粒体乙酰辅酶A/辅酶A的比例来激活丙酮酸脱氢酶，这一点在分离的脂肪细胞经洋地黄皂苷分级分离后得到了证实。

FEBS Lett. 1978 Sep 15;93(2):307-11. doi: 10.1016/0014-5793(78)81127-2.

2

Control of pyruvate dehydrogenase interconversion by palmitoyl-coenzyme A as related to adenine nucleotide translocation in isolated fat cell mitochondria.

FEBS Lett. 1975 Dec 15;60(2):269-74. doi: 10.1016/0014-5793(75)80729-0.

3

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.辅酶A-SH：乙酰辅酶A、烟酰胺腺嘌呤二核苷酸：还原型烟酰胺腺嘌呤二核苷酸以及二磷酸腺苷：三磷酸腺苷的比例对分离的大鼠心脏线粒体中活性和非活性丙酮酸脱氢酶相互转化影响的研究

J Biol Chem. 1976 Sep 25;251(18):5483-9.

4

Proceedings: Control of pyruvate dehydrogenase interconversion by palmitoyl-coenzyme A as related to inhibition of adenine nucleotide translocation in isolated fat-cell mitochondria.

Hoppe Seylers Z Physiol Chem. 1974 Oct;355(10):1268.

5

Control of fatty acid synthesis in white adipose tissue by insulin: coordination between the mitochondrial citrate transporter and pyruvate dehydrogenase.

Can J Biochem. 1974 Oct;52(10):814-21.

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Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.糖尿病与大鼠心脏线粒体中丙酮酸脱氢酶的调控：通过三磷酸腺苷/二磷酸腺苷、还原型/氧化型烟酰胺腺嘌呤二核苷酸以及乙酰辅酶A/辅酶A的浓度比进行调控

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Studies on the regulation of pyruvate dehydrogenase in the isolated perfused rat heart.离体灌注大鼠心脏中丙酮酸脱氢酶调节的研究。

J Biol Chem. 1979 Feb 25;254(4):1252-8.

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Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide.大鼠心脏中丙酮酸脱氢酶的调节。脂肪酸和酮体氧化对去磷酸化和磷酸化酶比例的调节机制以及糖尿病的影响：辅酶A、乙酰辅酶A以及还原型和氧化型烟酰胺腺嘌呤二核苷酸的作用

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The regulation of pyruvate dehydrogenase by fatty acids in isolated rabbit heart mitochondria.

Arch Biochem Biophys. 1978 Apr 15;187(1):121-31. doi: 10.1016/0003-9861(78)90014-0.

10

Interrelationship in the regulation of pyruvate dehydrogenase and adenine-nucleotide translocase by palmitoyl-CoA in isolated mitochondria.

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Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery.单次腹腔注射肝毒性硫代乙酰胺后大鼠辅酶 A 和乙酰辅酶 A 浓度的变化与快速恢复不一致。

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Regulation of kinase reactions in pig heart pyruvate dehydrogenase complex.猪心脏丙酮酸脱氢酶复合体中激酶反应的调节

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