Buda A J, Macdonald I L, Kwok K L, Orr S A
Chest. 1982 Sep;82(3):285-90. doi: 10.1378/chest.82.3.285.
To determine the effect of coronary disease progression on left ventricular function, 47 patients who had two cardiac catheterizations at a mean interval of 25 months (range three to 92 months) without intervening surgery were studied. Of these, 35 patients had coronary disease and 12 patients had normal or near normal coronary arteries. Coronary disease progression was seen more often in patients with initial coronary disease than in those without significant disease (66 percent vs 25 percent, p less than 0.02). Left ventricular ejection fraction decreased in patients with coronary disease progression (0.63 +/- 0.03 to 0.51 +/- 0.04, p less than 0.01) but was unchanged in patients without progressive disease (0.58 +/- 0.04 to 0.57 +/- 0.93, p = NS). Interval myocardial infarction was the major cause of deteriorating left ventricular function. The rate or degree of coronary disease progression did not predictably change global left ventricular function, and progressive disease in individual vessels did not predictably alter regional left ventricular function. The presence or development of collateral vessels did not significantly alter ventricular performance.
为了确定冠心病进展对左心室功能的影响，我们对47例患者进行了研究，这些患者在平均间隔25个月（范围为3至92个月）的时间内接受了两次心脏导管检查，期间未进行介入手术。其中，35例患者患有冠心病，12例患者冠状动脉正常或接近正常。与无明显疾病的患者相比，初始患有冠心病的患者中冠心病进展更为常见（66% 对25%，p<0.02）。冠心病进展患者的左心室射血分数下降（从0.63±0.03降至0.51±0.04，p<0.01），而无疾病进展的患者左心室射血分数无变化（从0.58±0.04降至0.57±0.93，p=无显著性差异）。间歇性心肌梗死是左心室功能恶化的主要原因。冠心病进展的速率或程度并不能可预测地改变整体左心室功能，单个血管的疾病进展也不能可预测地改变局部左心室功能。侧支血管的存在或发展并未显著改变心室功能。
