Chesler E, Mitha A S, Edwards J E
Chest. 1982 Sep;82(3):334-7. doi: 10.1378/chest.82.3.334.
The unusual occurrence of non-infected submitral and aortic aneurysms developing sequentially in an adult prompted us to review the pathogenesis of congenital aneurysms adjacent to the aortic and mitral valves. The findings support the suggestion that subvalvular aneurysms, like aortic sinus aneurysms, are a result of a congenital defect at the valve anulus. Submitral aneurysms occur only subjacent to the posterior leaflet. Whereas aortic sinus aneurysms may arise from any of the three sinuses, subaortic aneurysms occur only under the intermediate portion of the left aortic sinus. In the absence of rupture, the clinical presentation of these aneurysms results from valvular insufficiency or compression of the left coronary artery or of the conduction system.
一名成年人先后出现非感染性二尖瓣下和主动脉瘤的罕见情况，促使我们回顾主动脉瓣和二尖瓣附近先天性动脉瘤的发病机制。研究结果支持以下观点：瓣下动脉瘤与主动脉窦瘤一样，是瓣膜环先天性缺陷的结果。二尖瓣下动脉瘤仅发生于后叶下方。虽然主动脉窦瘤可起源于三个窦中的任何一个，但主动脉下动脉瘤仅发生于左主动脉窦中间部分下方。在未破裂的情况下，这些动脉瘤的临床表现是由瓣膜功能不全或左冠状动脉或传导系统受压引起的。
