Maira G, Di Rocco C, Anile C, Roselli R
Childs Brain. 1982;9(3-4):205-10. doi: 10.1159/000120056.
The endocrinological alterations related to craniopharyngiomas are usually described as panhypopituitarism. The growth failure in the prepuberal child and/or the puberal retard are the clinical symptoms usually related to it. Nevertheless, for the peculiar diencephalic control of the prolactin (PRL) pituitary secretion, different endocrinological pictures can be observed, related to the different degree of pituitary-hypothalamic compression from the craniopharyngioma. For these reasons a dynamic PRL pre- and postoperative evaluation has been performed in 4 patients operated on for craniopharyngioma. A correlation has been made between hormonal picture, size and location of the tumor, and surgical results. The value of these data in performing an early diagnosis in children with craniopharyngioma is discussed.
与颅咽管瘤相关的内分泌改变通常被描述为全垂体功能减退。青春期前儿童生长发育迟缓及/或青春期发育延迟是通常与之相关的临床症状。然而，由于泌乳素（PRL）垂体分泌受间脑特殊调控，根据颅咽管瘤对垂体-下丘脑压迫程度不同，可观察到不同的内分泌表现。基于这些原因，对4例接受颅咽管瘤手术的患者进行了泌乳素术前及术后动态评估。对激素表现、肿瘤大小和位置以及手术结果之间进行了相关性分析。讨论了这些数据在颅咽管瘤患儿早期诊断中的价值。
