Cyclic changes of sialidase in human cervical mucus.

1. Sialidase activity is detectable in whole cervical mucus of normal women throughout the menstrual cycle and presents cyclic variations toward endogenous and exogenous substrates. 2. The level of sialic acid bound to the mucus increases progressively till mid-cycle and declines in the post-ovulatory phase. 3. The sialidase of the mucus probably derives from different sources and its role remains speculative.