Takehisa T
Fertil Steril. 1980 Feb;33(2):135-40. doi: 10.1016/s0015-0282(16)44533-4.
The glycolytic enzymes, lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase, and hexokinase in cervical mucus of 96 ovulatory women were serially measured daily during the menstrual cycle. Among all of the enzymes, the cyclic changes in LDH activity were the most significant, being high during the proliferative phase, gradually decreasing to the lowest level around ovulation, and then increasing markedly again. Estrogen inhibited cervical mucus LDH activity; progestrone accelerated it. Examination of the LDH isozyme pattern showed that H-LDH (H-subunit of LDH), being predominant throughout the cycle, apparently carries some responsibility for the cyclic change in LDH activity. In a comparison of LDH activity with the serum luteinizing hormone (LH) peak, the activity level nadir of LDH usually appeared between 1 day before and 1 day after the serum LH peak, pointing to the advantage of daily measurement of cervical mucus LDH activity for predicting the potential day of conception.
在96名处于排卵期的女性的月经周期中，每天连续测量其宫颈黏液中的糖酵解酶、乳酸脱氢酶（LDH）、葡萄糖-6-磷酸脱氢酶和己糖激酶。在所有这些酶中，LDH活性的周期性变化最为显著，在增殖期较高，在排卵前后逐渐降至最低水平，然后再次显著升高。雌激素抑制宫颈黏液LDH活性；孕酮则加速其活性。对LDH同工酶模式的检测表明，H-LDH（LDH的H亚基）在整个周期中占主导地位，显然对LDH活性的周期性变化负有一定责任。将LDH活性与血清促黄体生成素（LH）峰值进行比较时，LDH活性水平最低点通常出现在血清LH峰值前1天和后1天之间，这表明每天测量宫颈黏液LDH活性对于预测潜在受孕日具有优势。
