Sauer R, Thiel H J, Müller R
Fortschr Med. 1982 Jun 10;100(22):1047-53.
In the past years there is a worldwide renaissance in interstitial low dose-rate implantation of tumors in many sites of origin. This renaissance is due to the development of new artificial radioisotopes (Au-198, Ir-192 and particularly I-125), the refinement of application techniques with after-loading devices and the introduction of computerized dosimetry. It is the opinion of a number of widely experienced radiotherapists that interstitial implants represent the treatment of choice "par excellence" and one of the ways to overcome the treatment resistance of inoperable malignant tumors. For this reason we have introduced the method of permanent and removable implantation of inoperable brain tumors, head and neck cancers and prostate carcinomas with 125I-seeds at the University of Erlangen-Nürnberg. Our first clinical impressions are very encouraging. The techniques of implantation used, the properties and advantages of 125I-seeds, dosimetric considerations and problems related to radiation protection are described.
在过去几年中，肿瘤间质低剂量率植入在许多原发部位在全球范围内再度兴起。这种再度兴起归因于新的人工放射性同位素（金 - 198、铱 - 192，尤其是碘 - 125）的发展、后装装置应用技术的完善以及计算机剂量测定法的引入。许多经验丰富的放射治疗师认为，间质植入是“卓越的”首选治疗方法，也是克服无法手术的恶性肿瘤治疗抗性的方法之一。因此，我们在埃尔朗根 - 纽伦堡大学引入了用碘 - 125种子对无法手术的脑肿瘤、头颈癌和前列腺癌进行永久性和可移除性植入的方法。我们的初步临床印象非常令人鼓舞。文中描述了所使用的植入技术、碘 - 125种子的特性和优点、剂量测定考虑因素以及与辐射防护相关的问题。
