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1
Human monocyte binding of homologous monomer and complexed IgG.人单核细胞对同源单体和复合IgG的结合。
Immunology. 1982 Aug;46(4):793-800.
2
Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance.IgG Fc 部分的单核细胞受体：用单体人 IgG1 进行的研究——HLA - B8/Drw3 受试者体内 Fcγ 介导的清除存在缺陷但 Fcγ 受体的体外表达正常
J Immunol. 1982 Sep;129(3):1041-9.
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Increased Fc receptor activity in monocytes from patients with rheumatoid arthritis: a study of monocyte binding and catabolism of soluble aggregates of IgG in vitro.类风湿关节炎患者单核细胞中Fc受体活性增加：体外单核细胞对IgG可溶性聚集体的结合及分解代谢研究
J Immunol. 1981 Aug;127(2):643-7.
4
Quantitative studies of Fc receptors on human monocytes: characterization by binding of homologous and heterologous monomeric IgG and soluble immune complexes of different composition.人单核细胞上Fc受体的定量研究：通过同源和异源单体IgG以及不同组成的可溶性免疫复合物的结合进行表征。
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The binding of human immunoglobulin G1 monomer and small, covalently cross-linked polymers of immunoglobulin G1 to human peripheral blood monocytes and polymorphonuclear leukocytes.人免疫球蛋白G1单体及免疫球蛋白G1的小的、共价交联聚合物与人外周血单核细胞和多形核白细胞的结合
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Monocyte IgG-Fc receptors in myotonic dystrophy.强直性肌营养不良中的单核细胞IgG-Fc受体
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引用本文的文献

1
Quantitative studies of Fc receptors on human monocytes: characterization by binding of homologous and heterologous monomeric IgG and soluble immune complexes of different composition.人单核细胞上Fc受体的定量研究：通过同源和异源单体IgG以及不同组成的可溶性免疫复合物的结合进行表征。
Immunology. 1983 Jul;49(3):537-44.
2
Mononuclear phagocytes in rheumatoid arthritis: Fc-receptor expression by peripheral blood monocytes.类风湿关节炎中的单核吞噬细胞：外周血单核细胞的Fc受体表达
Ann Rheum Dis. 1984 Jun;43(3):424-9. doi: 10.1136/ard.43.3.424.
3
The stimulation of superoxide anion production in guinea-pig peritoneal macrophages and neutrophils by phorbol myristate acetate, opsonized zymosan and IgG2-containing soluble immune complexes.佛波酯、调理酵母聚糖和含IgG2的可溶性免疫复合物对豚鼠腹腔巨噬细胞和中性粒细胞中超氧阴离子产生的刺激作用。
Immunology. 1983 Apr;48(4):657-65.
4
Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac-1 antigen.识别Mac-1抗原的单克隆抗体抑制免疫球蛋白G介导的吞噬作用的机制。
J Clin Invest. 1988 Feb;81(2):365-75. doi: 10.1172/JCI113328.
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6
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J Clin Immunol. 1986 Nov;6(6):442-56. doi: 10.1007/BF00915250.
7
Quantitative assessment of Fc receptor expression and function during in vitro differentiation of human monocytes to macrophages.人单核细胞体外分化为巨噬细胞过程中Fc受体表达及功能的定量评估
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8
Immune complexes and rheumatoid factors in canine arthritides.犬类关节炎中的免疫复合物和类风湿因子。
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本文引用的文献

1
Macrophage handling of soluble immune complexes. Ingestion and digestion of surface-bound complexes at 4, 20 and 37 degrees C.巨噬细胞对可溶性免疫复合物的处理。在4℃、20℃和37℃下对表面结合复合物的摄取和消化。
Eur J Immunol. 1980 May;10(5):323-33. doi: 10.1002/eji.1830100503.
2
The binding of soluble immune complexes of guinea pig IgG2 to homologous peritoneal macrophages. Determination of the avidity constants at 4 degrees C.豚鼠IgG2可溶性免疫复合物与同源腹腔巨噬细胞的结合。4℃下亲和力常数的测定。
Eur J Immunol. 1980 May;10(5):317-22. doi: 10.1002/eji.1830100502.
3
Separation of human monocytes on density gradients of Percoll.利用Percoll密度梯度分离人单核细胞。
J Immunol Methods. 1980;33(3):221-9. doi: 10.1016/0022-1759(80)90209-4.
4
Loss of Fc receptor activity after culture of human monocytes on surface-bound immune complexes. Mediation by cyclic nucleotides.人单核细胞在表面结合免疫复合物上培养后Fc受体活性丧失。环核苷酸的介导作用。
J Exp Med. 1980 Jan 1;151(1):32-44. doi: 10.1084/jem.151.1.32.
5
Mechanism of binding of multivalent immune complexes to Fc receptors. 1. Equilibrium binding.多价免疫复合物与Fc受体的结合机制。1. 平衡结合。
Biochemistry. 1981 Oct 27;20(22):6326-34. doi: 10.1021/bi00525a007.
6
Increased Fc receptor activity in monocytes from patients with rheumatoid arthritis: a study of monocyte binding and catabolism of soluble aggregates of IgG in vitro.类风湿关节炎患者单核细胞中Fc受体活性增加：体外单核细胞对IgG可溶性聚集体的结合及分解代谢研究
J Immunol. 1981 Aug;127(2):643-7.
7
Enhanced degradation of soluble immune complexes by guinea-pig peritoneal macrophages in the presence of complement.在补体存在的情况下，豚鼠腹膜巨噬细胞对可溶性免疫复合物的降解增强。
Immunology. 1981 Jun;43(2):345-52.
8
Separation of human peripheral blood monocytes on continuous density gradients of polyvinylpyrrolidone-coated silica gel (Percoll).在聚乙烯吡咯烷酮包被的硅胶（Percoll）连续密度梯度上分离人外周血单核细胞。
J Immunol Methods. 1982;48(2):199-211. doi: 10.1016/0022-1759(82)90194-6.
9
Studies on antigen-antibody complexes. I. Elimination of soluble complexes from rabbit circulation.抗原-抗体复合物的研究。I. 兔循环系统中可溶性复合物的清除
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10
IgG subclass specificity of human monocyte receptor sites.人类单核细胞受体位点的IgG亚类特异性
Nature. 1971 Feb 5;229(5284):419-20. doi: 10.1038/229419a0.

人单核细胞对同源单体和复合IgG的结合。

Human monocyte binding of homologous monomer and complexed IgG.

作者信息

Carter S D, Leslie R G, Reeves W G

出版信息

Immunology. 1982 Aug;46(4):793-800.

PMID:7106843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555481/
Abstract

Human peripheral blood monocyte binding of homologous IgG has been studied using monomer and covalently cross-linked dimer and trimer. A competitive radioassay using enriched monocytes was employed to determine the association constant (Ka) and the number of receptor sites per cell. Monomer and dimer bound with very similar Ka values (7.15 X 10(7) and 7.14 X 10(7)LM-1) whereas a slightly higher figure was obtained with trimer (8.9 X 10(7)LM-1). The number of receptor sites for dimer and trimer (90.5 and 107.5 X 10(3)/cell, respectively) were much greater than for monomer (14.5 X 10(3)/cell). Inhibition of dimer and trimer binding by monomer gave heterogenous Scatchard plots, each with two components. These findings suggest that human peripheral blood monocytes possess two types of Fc receptor, one of high affinity binding monomer and complexes and one of low affinity which predominantly binds complexes.

摘要

利用单体、共价交联二聚体和三聚体对人外周血单核细胞与同源IgG的结合进行了研究。采用富集单核细胞的竞争性放射分析来确定结合常数（Ka）和每个细胞的受体位点数。单体和二聚体的结合具有非常相似的Ka值（7.15×10⁷和7.14×10⁷L⁻¹M⁻¹），而三聚体的Ka值略高（8.9×10⁷L⁻¹M⁻¹）。二聚体和三聚体的受体位点数（分别为90.5和107.5×10³/细胞）远多于单体（14.5×10³/细胞）。单体对二聚体和三聚体结合的抑制作用产生了异质性的Scatchard图，每个图都有两个成分。这些发现表明，人外周血单核细胞具有两种类型的Fc受体，一种是高亲和力的，可结合单体和复合物，另一种是低亲和力的，主要结合复合物。