de la Caffiniére J Y, Martin E, Humbel R, Konsbruck R
Int Orthop. 1982;6(1):15-25.
This experimental study is complementary to the clinical series of cartilaginous autografts in the knee for medial condylar necrosis. The aim was to determine the viability of the articular cartilage in a series of grafts with variable thickness of the underlying spongy bone. The study was done on 36 adult rabbits and the cartilage was studied by biochemical, histochemical and ultrastructural methods. The results are conclusive. The earliest abnormal signs in the first few weeks affect the thinnest grafts of 4 mm whereas the 12 mm thickness grafts hardly show any lesions. It is therefore possible to use large autogenic grafts for osteocartilaginous defects provided the proportion between the area of the articular surface and the underlying spongy bone of the graft is at least 1/4. Under these circumstances, cartilaginous deterioration will be avoided and reduce long term degeneration.
这项实验研究是对膝关节内侧髁坏死自体软骨移植临床系列研究的补充。目的是确定一系列具有不同厚度的松质骨下层的移植物中关节软骨的活力。该研究对36只成年兔子进行，通过生化、组织化学和超微结构方法对软骨进行研究。结果是确凿的。最初几周最早出现的异常迹象影响4毫米的最薄移植物，而12毫米厚的移植物几乎没有任何病变。因此，如果移植物的关节表面面积与下层松质骨之间的比例至少为1/4，则有可能将大型自体移植物用于骨软骨缺损。在这种情况下，将避免软骨退化并减少长期退变。
