Clark R M, Wilkinson R H, Mahoney L J, Reid J G, MacDonald W D
Int J Radiat Oncol Biol Phys. 1982 Jun;8(6):967-79. doi: 10.1016/0360-3016(82)90163-8.
Evidence is presented from a study of 680 patients followed over a period of 21 years that conservative treatment of breast cancer by local excision of the primary tumor followed by breast irradiation yields results equivalent to the traditional radical approach, with the added benefit of an excellent cosmetic result and improved quality of life. The relative survivals were 8.3% at 5 years and 71% at 10 years. There was no difference in survival when radiation was given. Breast irradiation significantly reduced relapse in the breast, but axillary irradiation did not influence relapse at this site. Relapse in the breast alone was not detrimental to survival if treated appropriately. Axillary relapse indicated a much poorer prognosis as might be expected.
一项对680名患者进行了21年随访的研究表明，对乳腺癌采用局部切除原发肿瘤后进行乳房放疗的保守治疗方法，其效果与传统根治性手术相当，而且还有美容效果极佳和生活质量提高的额外益处。5年相对生存率为8.3%，10年为71%。放疗与否对生存率没有差异。乳房放疗显著降低了乳房复发率，但腋窝放疗对该部位复发没有影响。仅乳房复发如果得到适当治疗对生存并无不利影响。正如预期的那样，腋窝复发表明预后要差得多。
