Dunn G L, Morison D H, McChesney J, Pine W, Kumana C R, Gupta R N
J Clin Pharmacol. 1982 Jul;22(7):316-20. doi: 10.1002/j.1552-4604.1982.tb02681.x.
Plasma concentrations of minaxolone were measured in 15 female patients during and for up to 3 hours after a minaxolone and nitrous oxide anesthetic. Nine patients received a single dose and six patients two or three doses of minaxolone. Plasma minaxolone decay can be described by two-compartment kinetics. Distribution is rapid, with a mean half-life of 2.1 minutes, and the elimination half-life is short (47 minutes). Plasma clearance is high (1.55 l./min). Plasma levels of minaxolone at recovery were similar in patients receiving both single and multiple doses, suggesting a valid relationship between plasma level and effect. It is suggested that minaxolone may be a suitable agent for administration by continuous infusion.
在15名女性患者接受米那索龙与氧化亚氮麻醉期间及之后长达3小时内，测定了她们血浆中的米那索龙浓度。9名患者接受了单剂量米那索龙，6名患者接受了两剂或三剂米那索龙。血浆米那索龙的衰减可用二室动力学描述。分布迅速，平均半衰期为2.1分钟，消除半衰期较短（47分钟）。血浆清除率较高（1.55升/分钟）。接受单剂量和多剂量的患者在恢复时血浆米那索龙水平相似，这表明血浆水平与效应之间存在有效关系。有人提出米那索龙可能是一种适合持续输注给药的药物。
