Martelli H, Devroede G, Arhan P, Duguay C, Dornic C, Faverdin C
Gastroenterology. 1978 Oct;75(4):612-8.
This study presents normal values of bowel habits, colonic transit times of radioopaque markers, and anorectal pressure obtained from 114 normal subjects. Their stool frequency ranged from 3 to 11 per 7 days, whereas their diet contained an average of 14.4 g of crude fibers. Radioopaque markers progressed regularly along the large bowel and a range of transit times was established for its different segments. Manometric studies included measurements of anal pressure at rest, amplitude and duration of the rectoanal inhibitory reflex, anal inflation reflex, and amplitude of rectal contraction in response to rectal distension. Normal ranges were established. Amplitude, duration and magnitude (as measured by planimetry) of anal relaxation elicited by rectal distensions were related to rectal distending volume (P less than 0.001). The incidence of spontaneous variations of anal pressure at rest and of overshoot of pressure after the inhibitory reflex was also established. These data obtained on normal subjects may be compared to those obtained in patients with constipation in order to define the symptoms and to understand pathophysiological mechanisms. This has been done in a companion study.
本研究给出了114名正常受试者的排便习惯、不透X线标志物的结肠运输时间以及肛肠压力的正常值。他们的排便频率为每7天3至11次，而其饮食中平均含有14.4克粗纤维。不透X线标志物在大肠中规律推进，并确定了其不同节段的一系列运输时间。压力测量研究包括静息时肛门压力、直肠肛门抑制反射的幅度和持续时间、肛门扩张反射以及直肠扩张时直肠收缩幅度的测量。确定了正常范围。直肠扩张引起的肛门松弛的幅度、持续时间和大小（通过平面测量法测量）与直肠扩张体积相关（P<0.001）。还确定了静息时肛门压力自发变化以及抑制反射后压力过冲的发生率。在正常受试者身上获得的这些数据可与便秘患者的数据进行比较，以明确症状并了解病理生理机制。在一项配套研究中已进行了此项工作。
