Materossi C, Maoret T, Rozzini R, Spano P F, Trabucchi M
J Neural Transm. 1982;53(4):257-64. doi: 10.1007/BF01252037.
Following right middle cerebral artery occlusion in the rat, striatal dopaminergic system alterations were studied. Dopamine turnover was assessed by measuring 3,4-dihydroxyphenylacetic acid concentrations and dopamine receptor function, by measuring (3H)-Spiroperidol binding. There was a transient decrease in 3,4-dihydroxyphenylacetic acid and permanent damage to dopamine receptors, as indicated by a time-dependent progressive reduction in the number of (3H)-Spiroperidol binding sites. The receptor deficit also manifested as turning behaviour towards the lesioned side 4 weeks after the lesion following subcutaneous apomorphine. Long-term changes of dopaminergic receptor activity in this experimental model of cerebral infarction may be secondary to cortical degeneration following middle cerebral artery occlusion.
在大鼠大脑中动脉右侧闭塞后，对纹状体多巴胺能系统的改变进行了研究。通过测量3,4 - 二羟基苯乙酸浓度评估多巴胺代谢，通过测量（3H）- 螺哌啶醇结合评估多巴胺受体功能。3,4 - 二羟基苯乙酸出现短暂下降，多巴胺受体出现永久性损伤，表现为（3H）- 螺哌啶醇结合位点数量随时间逐渐减少。皮下注射阿扑吗啡后4周，受体缺陷还表现为向损伤侧的旋转行为。在这个脑梗死实验模型中，多巴胺能受体活性的长期变化可能继发于大脑中动脉闭塞后的皮质变性。
