Kurita A, Azorin J, Granier A, Bourassa M G
Jpn Circ J. 1982 Sep;46(9):964-73. doi: 10.1253/jcj.46.964.
The present study was attempted to determine whether a reduction in regional venous maximal coronary flow can indicate the presence of significant coronary stenosis. The great cardiac vein flow and the coronary sinus outflow were measured simultaneously in 8 open-chest dogs by a continuous thermodilution technique using a triple thermister catheter or two separate thermister catheters. The left anterior descending and circumflex coronary inflows were recorded using electromagnetic flow probes. Successive 70% coronary arterial stenosis maximal coronary flow and coronary reserve decreased significantly in the great cardiac vein and the coronary sinus. Significant correlations were found between the flows in the left anterior descending artery and in the great cardiac vein (r = 0.81) and between those in the circumflex artery and in the coronary sinus minus the great cardiac vein (r = 0.79) throughout the periods of preocclusion, occlusion and reactive hyperemic response. There were no significant changes in heart rate and hemodynamics. Using continuous thermodilution techniques, the inflows of the left anterior descending and the circumflex coronary arteries at a stenosis greater than 70% could be estimated from the changes in regional venous outflows.
本研究试图确定局部静脉最大冠脉血流减少是否可提示存在显著的冠脉狭窄。通过使用三热敏电阻导管或两根独立的热敏电阻导管的连续热稀释技术，对8只开胸犬同时测量了心大静脉血流和冠状窦流出量。使用电磁血流探头记录左前降支和左旋支冠脉血流。连续70%冠脉动脉狭窄时，心大静脉和冠状窦的最大冠脉血流和冠脉储备显著降低。在整个预闭塞、闭塞和反应性充血反应期间，左前降支动脉血流与心大静脉血流之间（r = 0.81）以及左旋支动脉血流与冠状窦减去心大静脉的血流之间（r = 0.79）均发现显著相关性。心率和血流动力学无显著变化。使用连续热稀释技术，可根据局部静脉流出量的变化来估计狭窄大于70%时左前降支和左旋支冠脉的血流。
