Shieh S D, Hirsch S R, Boshell B R, Pino J A, Alexander L J, Witten D M, Friedman E A
Kidney Int. 1982 May;21(5):739-43. doi: 10.1038/ki.1982.91.
The risk of developing contrast media-induced acute renal failure was studied in 49 randomly selected nonazotemic type 2 adult diabetic patients subjected to IVU. There were 19 men and 30 women in the group whose mean age was 62 +/- 10 years (range, 38 to 82 years). In preparation for IVU, patients were neither dehydrated nor given a laxative. The IVU was performed in the morning, using sodium diatrizoate and meglumine diatrizoate. Serum creatinine levels were measured pre-IVU and on days 1, 3, and 6 after the IVU. A total of three patients (6%) had an elevation of serum creatinine greater than 25% above the baseline by post-IVU day 3. One patient developed oliguria (less than 400 ml/24 hr) that lasted 2 days. Creatinine clearances of the three patients showing contrast media toxicity were 74, 60, and 105 ml/min pre-IVU. In each of the three patients, a return to pre-IVU serum creatinine concentration was noted within 2 weeks. It is concluded that the risk of acute renal failure post-IVU is small in hydrated nonazotemic type 2 diabetic patients.
对49例随机选取的非氮质血症型成年2型糖尿病患者进行静脉肾盂造影（IVU），研究发生造影剂诱发急性肾衰竭的风险。该组有19名男性和30名女性，平均年龄为62±10岁（范围38至82岁）。在准备IVU时，患者既未脱水也未给予泻药。IVU于上午进行，使用泛影酸钠和葡甲胺泛影酸盐。在IVU前以及IVU后第1、3和6天测量血清肌酐水平。共有3例患者（6%）在IVU后第3天血清肌酐升高超过基线水平25%以上。1例患者出现少尿（<400 ml/24小时），持续2天。显示造影剂毒性的3例患者在IVU前的肌酐清除率分别为74、60和105 ml/分钟。在这3例患者中每例均在2周内血清肌酐浓度恢复至IVU前水平。结论是，在水化的非氮质血症型2型糖尿病患者中，IVU后发生急性肾衰竭的风险较小。
