Silva de Sá M F, Meirelles R S
Gynecol Obstet Invest. 1978;9(1):49-56. doi: 10.1159/000300970.
The effect of estriol on the response of human umbilical artery to bradykinin (0.2 microgram/ml) and adrenalin (0.8 microgram/ml) was studied by an in vitro perfusion method. Estriol (10 microgram/ml) added to the nutrient medium decreased the response of the preparation to the two vasoactive agents. The results suggest the participation of estriol as a modulator of the vascular response at the level of the umbilical circulation, where it may act to protect the maternal-fetal circulatory system from physical or chemical stimuli.
采用体外灌注法研究了雌三醇对人脐动脉对缓激肽（0.2微克/毫升）和肾上腺素（0.8微克/毫升）反应的影响。向营养培养基中添加雌三醇（10微克/毫升）可降低制剂对这两种血管活性药物的反应。结果表明，雌三醇作为脐循环水平血管反应的调节剂发挥作用，在该循环中它可能起到保护母胎循环系统免受物理或化学刺激的作用。
