Molnár J, Mándi Y, Boda K, Földeák S
Neoplasma. 1982;29(2):215-22.
The effect of quaternary chlorpromazines like-methiodide, allylammonium chloride, -octylammonium iodide, benzylammonium chloride, -phenacylammonium bromide, 9-phenanthryl-methylammonium bromide, trimethylene-bis-chlorpromazine-ammonium bromide and among the ring-substituted derivatives the 7-hydroxy-, 7,8-dihydroxy-, 7,8-dioxo-, 6,9-dihydroxy-, 6,9-dioxo-chlorpromazines and the chlorpromazine-5-oxide on the prolongation of survival time of NK/Ly ascites tumor bearing mice was studied. The intraperitoneally administered quaternary chlorpromazine derivatives in 10-25 mg/kg daily dose did not increase the life span of the animals, and did not prevent the development of the ascites tumor. However some ring system substituted chlorpromazines such as the 7,8-dioxo- and 6,9-dioxo-derivatives markedly increased the survival time of the tumor bearing mice and reduced the ascite volume in 10 mg/kg body weight dose.
研究了季铵型氯丙嗪如氯丙嗪甲碘化物、烯丙基氯化铵、辛基碘化铵、苄基氯化铵、苯甲酰氯铵溴化物、9-菲甲基氯化铵溴化物、三亚甲基双氯丙嗪铵溴化物，以及环取代衍生物中的7-羟基-、7,8-二羟基-、7,8-二氧代-、6,9-二羟基-、6,9-二氧代-氯丙嗪和氯丙嗪-5-氧化物对荷NK/Ly腹水瘤小鼠存活时间延长的影响。每日腹腔注射剂量为10-25mg/kg的季铵型氯丙嗪衍生物并未延长动物的寿命，也未阻止腹水瘤的发展。然而，一些环系取代的氯丙嗪，如7,8-二氧代-和6,9-二氧代-衍生物，在10mg/kg体重剂量下显著延长了荷瘤小鼠的存活时间并减少了腹水体积。
