Gaddi A, Descovich G C, Lenzi S
Minerva Med. 1982 Sep 15;73(35):2261-8.
It is hypothesised, on the basis of experimental observations on post-heparin plasma samples collected under post-prandial conditions, that variations in the activity of endothelial lipoproteinlipasic systems may be correlated to reductions in blood flow at coronary capillary level. More specifically, it is shown that a change in these enzymatic systems could determine "functional kidnapping" of heparin or other substances (glicosaminoglycans) engaged in the activation of Antithrombin III, with noteworthy haemorrheological consequences mediated by a variety of mechanisms. Relations between such haemorheological and metabolic changes further to activation of lipoprotein lipase are discussed and stress is laid on the importance both might have in the pathogenesis of myocardial infarction.
基于在餐后条件下采集的肝素化血浆样本的实验观察结果，有假设认为，内皮脂蛋白脂肪酶系统活性的变化可能与冠状动脉毛细血管水平的血流减少相关。更具体地说，研究表明，这些酶系统的变化可能会导致肝素或其他参与抗凝血酶III激活的物质（糖胺聚糖）的“功能性扣留”，并通过多种机制产生显著的血液流变学后果。本文讨论了脂蛋白脂肪酶激活后血液流变学和代谢变化之间的关系，并强调了两者在心肌梗死发病机制中的重要性。
