Halliwell J V, Dolly J O
Neurosci Lett. 1982 Jun 30;30(3):321-7. doi: 10.1016/0304-3940(82)90420-7.
The action of beta-bungarotoxin on the transverse slice of rat hippocampus has been studied in vitro. The toxin (230 nM) initially impaired neurotransmission in the major subdivisions of the slice with a half time for blockade of about 10 min. Intracellular recordings revealed no reduction in pyramidal cell sensitivity to putative neurotransmitters, suggesting a primary action of the toxin upon transmitter release. More protracted effects of beta-bungarotoxin included a reduction of neuronal excitability, particularly in the terminal regions of hippocampal fibre pathways, but these proceeded at a much slower rate than the action on synaptic transmission. It is concluded that the toxin binds to some component present at terminal regions to mediate its preferential effect in the hippocampus.
已在体外研究了β-银环蛇毒素对大鼠海马横切片的作用。该毒素（230 nM）最初损害切片主要亚区的神经传递，阻断的半衰期约为10分钟。细胞内记录显示锥体细胞对假定神经递质的敏感性没有降低，这表明该毒素对递质释放具有主要作用。β-银环蛇毒素更持久的作用包括神经元兴奋性降低，特别是在海马纤维通路的终末区域，但这些作用的进展速度比其对突触传递的作用要慢得多。得出的结论是，该毒素与终末区域存在的某些成分结合，以介导其在海马体中的优先作用。
