Rohrbaugh T M, Danish M, Ragni M C, Yaffe S J
Pediatr Pharmacol (New York). 1982;2(1):75-83.
An oral theophylline product was given to eight lean, normal subjects and eight obese subjects (four with asthma and four normals) in a single-dose study. The mean apparent volume of distribution (Vd) was 0.472 +/- 0.08 liters/kg for the lean group and 0.321 +/- 0.063 liters/kg for the obese group (P less than 0.001). When Vd wax expressed in liters, there was no difference between the two groups (lean:26.9 +/- 6.0 liters, obese: 28.5 +/- 6.3 liters). An inverse relationship existed between the ratio of total body weight to ideal body weight (TBW/IBW) and Vd expressed in liters/kg. One obese subject was studied before and after a weight loss of about 32 kg. The values of Vd in this subject were 32.1 and 34.9 liters, respectively. These data indicated that theophylline is not extensively distributed into adipose tissue and that loading-dose calculations should be based on ideal body weight. No difference in clearance of theophylline was seen between the two groups.
在一项单剂量研究中，给8名瘦的正常受试者和8名肥胖受试者（4名哮喘患者和4名正常人）服用了一种口服茶碱产品。瘦组的平均表观分布容积（Vd）为0.472±0.08升/千克，肥胖组为0.321±0.063升/千克（P<0.001）。当Vd以升为单位表示时，两组之间没有差异（瘦组：26.9±6.0升，肥胖组：28.5±6.3升）。总体重与理想体重之比（TBW/IBW）与以升/千克表示的Vd之间存在反比关系。对一名肥胖受试者在体重减轻约32千克前后进行了研究。该受试者的Vd值分别为32.1升和34.9升。这些数据表明，茶碱不会广泛分布到脂肪组织中，负荷剂量的计算应基于理想体重。两组之间茶碱的清除率没有差异。
