Marchal F, Corke B C, Sundell H
Pediatr Res. 1982 Aug;16(8):621-7. doi: 10.1203/00006450-198208000-00007.
The laryngeal chemoreflex was studied during quiet and REM sleep and wakefulness in premature newborn lambs. The response to reflex stimulation with a 5 sec-water infusion was evaluated during 30 sec, as % change in ventilation, heart rate and blood pressure. Apnea, hypertension and bradycardia were more pronounced during sleep than during wakefulness, when arousal was not associated with the stimulation. The response was similar during quiet and REM sleep. Arousal, which occurred in 24 and 31% of the tests respectively, resulted in a response comparable to that seen during wakefulness. The respiratory drive was evaluated by measurement of the mean inspiratory flow and was found to be decreased during both sleep states when compared to wakefulness. We propose that during sleep in the newborn period there is a decreased ability to respond to asphyxia possibly due to a functional immaturity of the arterial chemoreceptors. This results in a low incidence of arousal and a delayed termination of the pronounced poststimulus apnea resulting from laryngeal chemoreflex stimulation.
在早产新生羔羊的安静睡眠、快速眼动睡眠和清醒状态下研究了喉化学反射。在30秒内评估用5秒水灌注进行反射刺激后的反应，以通气、心率和血压的变化百分比表示。当觉醒与刺激无关时，睡眠期间的呼吸暂停、高血压和心动过缓比清醒时更明显。安静睡眠和快速眼动睡眠期间的反应相似。分别在24%和31%的测试中出现的觉醒导致的反应与清醒时相当。通过测量平均吸气流量评估呼吸驱动力，发现与清醒相比，两种睡眠状态下呼吸驱动力均降低。我们提出，在新生儿期睡眠期间，对窒息的反应能力下降，这可能是由于动脉化学感受器功能不成熟所致。这导致觉醒发生率低，以及喉化学反射刺激引起的明显刺激后呼吸暂停延迟终止。
